My major research areas include the fields of medicinal chemistry & chemical biology, but also the total synthesis of natural products as well as drug targeting approaches. I am particularly focusing on the design of covalent protein kinase inhibitors and the development of novel electrophilic warheads for covalent targeting. Special emphasis is placed on the development of highly selective chemical probes for mapping the untargeted kinome. My group is further involved in several collaborative reserach projects e.g. on inhibitors for HECT E3 ubiquitin ligases and other targets.