ProjectCSBIARP – Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens

Basic data

Acronym:
CSBIARP
Title:
Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens
Duration:
01/07/2022 to 31/07/2025
Abstract / short description:
The increasing worldwide spread of antibiotic resistance in pathogenic bacteria requires the development of novel therapeutic approaches. In this project, systems biology modeling and computer simulation methods will systematically identify previously unknown weak points of harmful germs. As a novelty, genome-scale models of specific pathogens will be included in addition to the microbial totality and in conjunction with the human host. Thus, the full potential of computer analysis unfolds since, besides searching for new intracellular targets, effects such as biofilm formation or quorum sensing (i.e., molecular communication) or the immune response can also be used for treatment with suitable active substances. In this way, probiotic effects that promote the growth of symbiotic strains that naturally inhibit pathogens could be imitated. For this purpose, the models to be developed must first be adapted precisely to the human host, i.e., personalized. Therefore, the research aims to develop specific models of bacterial germs, which include their interaction with the surrounding microbiome and the human host. After personalizing the patients to be treated, the systematic computer analysis of these large-scale, detailed models should enable targeted interventions in the microbiome and thus open up the effectiveness of novel probiotic treatment methods. In this way, an alternative to previous antibiotic treatments could be achieved in the longer term.
Keywords:
systems biology
Systembiologie
computer simulation
Computersimulation
microbiome
Mikrobiom
personalized medicine
Personalisierte Medizin

Involved staff

Managers

Wilhelm Schickard Institute of Computer Science (WSI)
Department of Informatics, Faculty of Science
Center for Bioinformatics (ZBIT)
Centers

Local organizational units

Wilhelm Schickard Institute of Computer Science (WSI)
Department of Informatics
Faculty of Science
Center for Bioinformatics (ZBIT)
Centers
University of Tübingen

Funders

Braunschweig, Niedersachsen, Germany
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