ProjectSARS-CoV-2 – Die Bedeutung des antiviralen Faktors Tetherin für die Ausbreitung von SARS-CoV-2
Basic data
Acronym:
SARS-CoV-2
Title:
Die Bedeutung des antiviralen Faktors Tetherin für die Ausbreitung von SARS-CoV-2
Duration:
10/07/2020 to 30/06/2021
Abstract / short description:
The role of the antiviral host factor tetherin for the spread of SARS-CoV-2
Zoonotic viruses such as SARS-CoV-2 frequently have to adapt to their new human host in order to spread successfully in the population. One important hurdle that many viruses have to overcome is the antiviral factor tetherin. This project investigates how SARS-CoV-2 manages to evade restriction by tetherin. The results will not only help to better understand adaptations that contribute to the spread of coronaviruses, but will also improve our understanding of the animal origins of SARS-CoV-2 and identify potential therapeutic targets in the viral replication cycle.
Zoonotic viruses such as SARS-CoV-2 frequently have to adapt to their new human host in order to spread successfully in the population. One important hurdle that many viruses have to overcome is the antiviral factor tetherin. This project investigates how SARS-CoV-2 manages to evade restriction by tetherin. The results will not only help to better understand adaptations that contribute to the spread of coronaviruses, but will also improve our understanding of the animal origins of SARS-CoV-2 and identify potential therapeutic targets in the viral replication cycle.
Keywords:
SARS-COV-2
Tetherin
Involved staff
Managers
Faculty of Medicine
University of Tübingen
University of Tübingen
Institute of Medical Virology and Epidemiology of Viral Diseases
Department of Diagnostic Laboratory Medicine, Hospitals and clinical institutes, Faculty of Medicine
Department of Diagnostic Laboratory Medicine, Hospitals and clinical institutes, Faculty of Medicine
Other staff
Universität Tübingen
Faculty of Medicine
University of Tübingen
University of Tübingen
Lotke, Rishikesh
Faculty of Medicine
University of Tübingen
University of Tübingen
Faculty of Medicine
University of Tübingen
University of Tübingen
Department of Pharmacy and Biochemistry
Faculty of Science
Faculty of Science
Local organizational units
Institute of Medical Virology and Epidemiology of Viral Diseases
Department of Diagnostic Laboratory Medicine
Hospitals and clinical institutes, Faculty of Medicine
Hospitals and clinical institutes, Faculty of Medicine
Funders
Stuttgart, Baden-Württemberg, Germany