ProjectMWK COVID-19 Sonderf – Funktion und Immunogenität kryptischer ORF3-Proteine von SARS-CoV-2

Basic data

Acronym:
MWK COVID-19 Sonderf
Title:
Funktion und Immunogenität kryptischer ORF3-Proteine von SARS-CoV-2
Duration:
7/10/2020 to 6/30/2021
Abstract / short description:
Activity and immunogenicity of cryptic ORF3 proteins encoded by SARS-CoV-2
One remarkable feature of SARS-CoV-2 is the presence of multiple cryptic open reading frames (ORFs) in its ORF3 locus. Preliminary findings suggest that several of these ORFs encode proteins and peptides suppressing innate immune responses. The primary goal of this project is to characterize the (immunosuppressive) activities of these cryptic proteins and their roles in the viral replication cycle. Furthermore, the immunogenicity of proteins and peptides encoded by the ORF3 locus will be analyzed.
Keywords:
COVID-19 Sonderörderung

Involved staff

Managers

Faculty of Medicine
University of Tübingen
Institute of Medical Virology and Epidemiology of Viral Diseases
Department of Diagnostic Laboratory Medicine, Hospitals and clinical institutes, Faculty of Medicine

Other staff

Faculty of Medicine
University of Tübingen
Universität Tübingen
Faculty of Medicine
University of Tübingen

Local organizational units

Institute of Medical Virology and Epidemiology of Viral Diseases
Department of Diagnostic Laboratory Medicine
Hospitals and clinical institutes, Faculty of Medicine
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