The skin microbiome in resistance to Staphylococcus aureus colonization

01/07/2019 to 30/06/2023

How beneficial, ‘commensal’ skin bacteria can protect against Staphylococcus aureus colonization and how such processes can be exploited for preventive and therapeutic avenues e.g. in atopic dermatitis remains to be elucidated. We found the tripartite interaction of S. aureus, commensals, and the host to depend either on direct interaction e.g. via the novel microbiome-derived antibiotic lugdunin or on influencing skin defense mechanisms. We propose a comprehensive research program on the mechanisms of microbiome-mediated pathogen exclusion and on microbiome-host cell communication as a basis for innovative interventions in microbiome-associated skin diseases.