Pathogen and host-derived lipid membranes governing Staphylococcus aureus-mediated skin inflammation

01/08/2018 to 31/07/2021

Human skin is colonized by a complex microbiome constantly releasing pro-inflammatory microbe-associated molecular pattern (MAMP) molecules. It has remained largely unclear how permanent skin inflammation is avoided while invading pathogens
still lead to rapid pro-inflammatory responses. Our project will help to elucidate key processes of bacterial MAMP releases and of skinbarrier function and it should inspire better clinical interventions against skin inflammation in AD patients and other chronic inflammatory skin diseases.