ProjectSFB TRR 156/1 TP A01 – How skin inflammation is shaped by interaction of Staphylococcus aureus with skin cells and…
Basic data
Acronym:
SFB TRR 156/1 TP A01
Title:
How skin inflammation is shaped by interaction of Staphylococcus aureus with skin cells and skin microbiota
Duration:
01/07/2015 to 30/06/2019
Abstract / short description:
The skin of atopic dermatitis (AD) patients but not of healthy individuals is usually colonized by Staphylococcus aureus, which is thought to contribute to skin inflammation. The capacities of S. aureus to prevail in AD skin microbiota and modulate skin inflammation have hardly been investigated. We have explored pro- and anti-inflammatory S. aureus molecules, studied mechanisms of microbiota interaction, and established in vitro and in vivo skin colonization models. We will analyse how S. aureus adjusts a favourable level of skin inflammation and which role bacteriocins or metabolic capacities play in the competition with other skin bacteria. Our project should help to find new ways for treating bacteria-associated skin disorders.
Involved staff
Managers
Interfaculty Institute of Microbiology and Infection Medicine (IMIT)
Interfaculty Institutes
Interfaculty Institutes
Cluster of Excellence: Controlling Microbes to Fight Infections (CMFI)
Centers or interfaculty scientific institutions
Centers or interfaculty scientific institutions
Contact persons
Department of Dermatology
Hospitals and clinical institutes, Faculty of Medicine
Hospitals and clinical institutes, Faculty of Medicine
Cluster of Excellence: Image-Guided and Functionally Instructed Tumor Therapies (iFIT)
Centers or interfaculty scientific institutions
Centers or interfaculty scientific institutions
Research training group: Non-canonical G protein signaling pathways
Research training groups
Research training groups
Local organizational units
Interfaculty Institute of Microbiology and Infection Medicine (IMIT)
Interfaculty Institutes
University of Tübingen
University of Tübingen
Funders
Bonn, Nordrhein-Westfalen, Germany