PortfolioLucas Matt

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Academic title:
Lucas Matt
Organizational units:
Faculty of Science
University of Tübingen
Pharmaceutical Institute
Department of Pharmacy and Biochemistry

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Curriculum vitae

Research focus

The Role of Structural Proteins in Postsynaptic Plasticity. All proteins contributing to plastic changes of synaptic transmission are part of macromolecular complexes. These involve structural proteins such as PSD-95, the major organizer of the postsynaptic site, but also components of the cytoskeleton like F-actin and α-actinin. I study the components of these complexes with the goal to elucidate how the system allows plastic changes in response to a variety of stimuli.

The components of synaptic plasticity play important roles in Excitotoxicity During Ischemic Stroke. Exhaustive overstimulation is a pathophysiological hallmark of stroke where plasticity mechanisms contribute to negative outcome. I am interested in how the postsynaptic machinery can be modified to lessen the destructive effects of excitotoxicity.

The emergence of aberrant synaptic connections during brain development is typical for Autism Spectrum Disorders (ASD). It has been shown that many proteins of the synaptic site that are important for synaptic plasticity are genetic markers associated with ASD. How do these proteins contribute to the development of functional synapses and what can be done to improve chances of regular development?



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