ProjectBROOC – Brain organoid-on-chip: a microfluidic platform to study neocortical development

Basic data

Acronym:
BROOC
Title:
Brain organoid-on-chip: a microfluidic platform to study neocortical development
Duration:
01/09/2022 to 31/08/2024
Abstract / short description:
A sophisticated human model of neocortex development is required for the study of autism spectrum disorders and intellectual disability. So far, neural 2D cultures have been used but they haven’t the tissue complexity required. The EU-funded BROOC project has proposed development of controlled 3D spatio-temporal using Organ-on-chip (OoC) technology. The result, a new cerebral organoid model with multi-layered cortex structures on a microfluidic chip system within an array of integrated electrodes. This OoC platform will enable study of application of pharmaceuticals and neurodevelopmental disorders. Moreover, the technology will provide an alternative to the use of animals and provide a tool to study the molecular mechanisms of brain evolution.

Involved staff

Managers

Department of Gynecology and Obstetrics
Center for Women's Health, Hospitals and clinical institutes, Faculty of Medicine

Other staff

Department of Gynecology and Obstetrics
Center for Women's Health, Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

Faculty of Medicine
University of Tübingen

Funders

Brüssel, Belgium
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