ProjectPharmacodynamic Relevance of Promotor methylation in IGF1
Basic data
Title:
Pharmacodynamic Relevance of Promotor methylation in IGF1
Duration:
01/02/2021 to 31/01/2022
Abstract / short description:
Aim ist to study the degree of methylation of the gene IGF1 in short children treated with growth hormone and to compare the methylation with the treatment response.
IGF1 encodes the Insulin-like growth factor 1, a major gowth factor regulated by growth hormone. The studied cells will be blood leukocytes. We are going to compare the degree of methylation with the - retrospectively examined - first year growth velocity and IGF-1 serum levels and expect an inverse relationship.
IGF1 encodes the Insulin-like growth factor 1, a major gowth factor regulated by growth hormone. The studied cells will be blood leukocytes. We are going to compare the degree of methylation with the - retrospectively examined - first year growth velocity and IGF-1 serum levels and expect an inverse relationship.
Keywords:
endocrinology
growth disorders
IGF1 promotor methylation
response to growth hormone treatment
Involved staff
Managers
University Children’s Hospital - Department of Paediatrics
Hospitals and clinical institutes, Faculty of Medicine
Hospitals and clinical institutes, Faculty of Medicine
Local organizational units
University Children’s Hospital - Department of Paediatrics
Hospitals and clinical institutes
Faculty of Medicine
Faculty of Medicine
Funders
Mainz, Rheinland-Pfalz, Germany