ProjectCMFI MicrobImage – Real-time imaging of gut microbiome modulation

Basic data

Acronym:
CMFI MicrobImage
Title:
Real-time imaging of gut microbiome modulation
Duration:
01/04/2022 to 01/04/2025
Abstract / short description:
The importance of the gastrointestinal microbiome has been known for over a century, and its imbalances may lead to various life threatening diseases. Strategies aiming at restoring this balance have thus been developed with various amounts of success. The development of such therapies is however hindered by a lack of understanding of the dynamics of the microbiome, an issue compounded by the lack of species-specific in vivo monitoring tools. We propose to develop a novel preclinical Positron Emission Tomography approach based on metabolic engineering enabled click chemistry of radiotracers, which allows highly sensitive, quantitative and species-specific imaging of gut bacteria in vivo. We will apply this approach in a murine model of Salmonella Typhimurium (S. Tm) infection to investigate the protective effect of the probiotic E. coli Nissle and the influence of prebiotics on S. Tm dissemination.
Keywords:
microbiome
Mikrobiom
PET
positron emission tomography, Positronen-Emissions-Tomographie
infection biology
Infektionsbiologie

Involved staff

Managers

Faculty of Medicine
University of Tübingen
Faculty of Medicine
University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine (IMIT)
Interfaculty Institutes
Cluster of Excellence: Controlling Microbes to Fight Infections (CMFI)
Centers or interfaculty scientific institutions

Local organizational units

Department of Preclinical Imaging and Radiopharmacy
Department of Radiology
Hospitals and clinical institutes, Faculty of Medicine
Institute of Medical Microbiology and Hygiene
Department of Diagnostic Laboratory Medicine
Hospitals and clinical institutes, Faculty of Medicine
Help

will be deleted permanently. This cannot be undone.