ProjectImmuno-thermal therapy for targeting immune networks to control melanoma metastasis

Basic data

Immuno-thermal therapy for targeting immune networks to control melanoma metastasis
01/01/2022 to 31/12/2022
Abstract / short description:
Immunotherapy is an emerging first-line treatment to target advanced cancer, with the potential to reach long-lasting regression and cure. Most solid tumors initially respond to immunotherapy; however, the majority of patients experience therapy-resistance followed by relapse. Cell-based immunotherapies focus on activating or directly engineering tumor-specific cytotoxic cells (CTL), which are infused in the patient to mediate tumor elimination. However, a successful immune response is controlled by a network of highly-specialized immune cell subtypes which, in response to functional parameters of the microenvironment, steer immune decisions towards tolerance or anti-tumor effector function. Consequently, CTL can be found infiltrating the tumor in patients, but their killing capacity is often rapidly shut-down by local, suppressive immune networks. Fever-range thermal therapy is a potential strategy to convert immunosuppressive tumor tissue niches into a proinflammatory microenvironment. Thermal therapy is a clinically emerging therapy that is based on strong biological rationale and is empirically effective, but largely lacks a mechanistic framework. By using a world-wide unique multiscale imaging workflow, consisting of (i) in vivo intravital multiphoton microscopy (iMPM) of the primary melanoma lesion, (ii) ex vivo 3D light-sheet microscopy (LSM) of melanoma metastases and (iii) translational immuno-PET/MR imaging of systemic immune activation and function, we aim to decipher the molecular and cellular mechanisms that mediate immuno-thermal therapy efficacy and potential side effects. A deeper understanding of the interplay between immuno- and thermal therapies will allow to better exploit synergistic mechanisms to achieve sustained melanoma remission.

Involved staff


Faculty of Medicine
University of Tübingen
Research training group: Non-canonical G protein signaling pathways
Research training groups

Local organizational units

Department of Preclinical Imaging and Radiopharmacy
Department of Radiology
Hospitals and clinical institutes, Faculty of Medicine


München, Bayern, Germany

will be deleted permanently. This cannot be undone.