ProjectForschungsgruppe (FOR 2715) "Epileptogenese von genetischen Epilepsien" Teilprojekt TP 5: "Gehirnregion-abhängige…

Basic data

Title:
Forschungsgruppe (FOR 2715) "Epileptogenese von genetischen Epilepsien" Teilprojekt TP 5: "Gehirnregion-abhängige Epileptogenese in einem konditionalen Mausmodell"
Duration:
9/30/2021 to 9/29/2024
Abstract / short description:
Despite the identification of a steadily increasing number of epilepsy genes and elucidation of molecular mechanisms of disease‐causing mutations in heterologous expression systems, the exact mechanisms as to how epilepsy develops on the basis of a genetic defect is poorly understood. Functional studies in neurons and animal models offer interesting opportunities to understand the mechanisms underlying epileptogenesis and may pave the way for novel treatment options. Following the main hypothesis of this Research Unit (RU), epilepsy likely develops as a consequence of three interacting processes: the neurophysiological effect of the genetic mutation itself, an epileptogenic process triggered by the mutation, and developmentally regulated physiological changes of network properties within the brain. Therefore, we intend to understand the cascade caused by a molecular
genetic dysfunction that triggers cellular changes of neuronal excitability and consecutively affects network function over time ending in epileptic seizures.

Involved staff

Managers

Department of Neurosurgery
Department of Neurosurgery and Neurotechnology, Hospitals and clinical institutes, Faculty of Medicine
Department of Neurology and Epileptology
University Department of Neurology, Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

Department of Neurology and Epileptology
University Department of Neurology
Hospitals and clinical institutes, Faculty of Medicine
Department of Neurosurgery
Department of Neurosurgery and Neurotechnology
Hospitals and clinical institutes, Faculty of Medicine

Funders

Bonn, Nordrhein-Westfalen, Germany
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