ProjectSARS-Cov-2 – protACT - Aktivierung und therapeutische Hemmung des SARS-CoV-2 Spike-Proteins

Basic data

Acronym:
SARS-Cov-2
Title:
protACT - Aktivierung und therapeutische Hemmung des SARS-CoV-2 Spike-Proteins
Duration:
7/1/2020 to 12/31/2021
Abstract / short description:
The spike protein of SARS-CoV-2 harbors a poly-basic motif that can be cleaved by the ubiquitously expressed cellular protease furin. This project aims at deciphering the role of furin and related proteases in the activation of SARS-CoV-2 spike and the downstream effects on viral infectivity and replication. Furthermore, this study determines the impact of endogenous and exogenous furin inhibitors on SARS-CoV-2 replication. The project will not only provide important insights into the determinants of SARS-CoV-2 infectivity and tropism, but also help to assess consequences of mutations emerging during the current outbreak and might identify promising targets for therapeutic intervention.
Keywords:
proteins
Proteine
SARS-Cov-2
Spike-Protein

Involved staff

Managers

Faculty of Medicine
University of Tübingen
Institute of Medical Virology and Epidemiology of Viral Diseases
Department of Diagnostic Laboratory Medicine, Hospitals and clinical institutes, Faculty of Medicine

Other staff

Universität Tübingen
Faculty of Medicine
University of Tübingen
Department of Pharmacy and Biochemistry
Faculty of Science
Faculty of Medicine
University of Tübingen
Faculty of Medicine
University of Tübingen

Local organizational units

Institute of Medical Virology and Epidemiology of Viral Diseases
Department of Diagnostic Laboratory Medicine
Hospitals and clinical institutes, Faculty of Medicine

Funders

Bonn, Nordrhein-Westfalen, Germany
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