Metabolische Kontrolle des des G1/S Übergangs - Ein neues Modell für Start

01/11/2021 to 31/10/2024

Growth and division are regulated in response to nutrients. If nutrient supply is insufficient, cells do not commit to another round of division. This decision to irreversibly commit to the cell cycle takes place in G1 at the “restriction point” in mammals and “Start” in yeast, our model of choice. While clearly nutrient supply affects Start, it is not clear how nutrient supply affects yeast cells that have already passed Start. To solve this questions, we will combine single cell analysis with protein biochemistry.