ProjectVorhersage zukünftiger Myopie aus Änderungen der Aderhautdicke

Basic data

Title:
Vorhersage zukünftiger Myopie aus Änderungen der Aderhautdicke
Duration:
7/8/2021 to 10/31/2024
Abstract / short description:
In recent decades, the prevalence of myopia has increased dramatically in many countries around the world. Studies conducted first in animal models and later in humans show that the thickness of the choroid changes when the focal plane in the retinal image is shifted. With a positive lens in front of the eye, the choroid thickens within hours, moving the retina closer to the focal plane. With a negative lens, the choroid thins, again moving the retina closer to the focal plane. In the long term, the change in choroidal thickness is followed by a change in the growth of the outer layer of the eye, the sclera. In the last three years, it has been found that visual stimuli other than defocus can also increase choroidal thickness. It is not clear whether such changes can also reliably predict myopia inhibition. Studies with novel artificial visual stimuli in chickens showed that in some cases changes in choroidal thickness were uncoupled from changes in eye growth. Because researchers rely on the assumption that thicker choroid predicts lower myopia, the project will investigate (1) under what conditions these predictions are valid and (2) what mechanisms and biochemical pathways trigger such changes in choroidal thickness and scleral growth.
Keywords:
Kurzsichtigkeit
Aderhautdicke
Melanopsin

Involved staff

Managers

Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine

Contact persons

Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

Center for Ophthalmology
Hospitals and clinical institutes
Faculty of Medicine

Funders

Bonn, Nordrhein-Westfalen, Germany
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