ProjectMomentum-Maus – Implementing Novel Tools to Manipulate the Transcriptome in Mouse

Basic data

Acronym:
Momentum-Maus
Title:
Implementing Novel Tools to Manipulate the Transcriptome in Mouse
Duration:
4/1/2021 to 3/31/2026
Abstract / short description:
During the last years, my lab pioneered the field of site-directed RNA editing, which is a method to recode genetic information on the mRNA. Compared to gene editing, the method is much more efficient, can be performed on several transcripts in parallel, and is reversible. All this is advantageous if one wants to manipulate regulatory functions, which often leads to lethality or genetic compensation if done by means of genome editing. My research group has developed several RNA editing approaches, particularly the SNAP-ADAR and the RESTORE approach. Initially, all tools were examined exclusively in vitro, and in the meantime broadly established in cell culture. The next step is to test and further optimize the tools in vivo in order to exploit their full potential for basic research and for medical translation. Therefore, in a perspective extension of the professorship, the corresponding mouse work will be developed and established in the laboratory. The editing tools may be used to better understand disease mechanisms, or to interfere with essential biological processes such as inflammation or metabolism in the future. The aim is to establish the SNAP-ADAR approach in transgenic mice, which has not been tested in mice before.

Involved staff

Managers

Faculty of Science
University of Tübingen
Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes

Local organizational units

Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes
University of Tübingen

Funders

Hannover, Niedersachsen, Germany
Help

will be deleted permanently. This cannot be undone.