ProjektGEPIIiC – Shining a light on (sub)cellular K+ concentrations and dynamics in cancer cells
Grunddaten
Akronym:
GEPIIiC
Titel:
Shining a light on (sub)cellular K+ concentrations and dynamics in cancer cells
Laufzeit:
01.09.2020 bis 31.08.2021
Abstract / Kurz- beschreibung:
Identifying and exploring the importance of the intracellular K+ homeostasis as a key player regulating cancer cell malignancy and vulnerability has the potency to revolutionize our understanding of cell biology, harboring the potency to unveil yet unknown
backgrounds of cancer development and progression. Based on the generated K+ profile from different breast cancer cells, we aim for the specific manipulation of (sub)cellular K+ signals and concentrations within these cells and their organelles using “specific” K+ channel modulators. These imaging-based approaches will be complemented by the (correlative) assessment of
multiple cancer cell behavior parameters. Consequently, novel anti-cancer strategies and therapies based on the specific modulation of oncogenic K+ signals may evolve from our findings.
backgrounds of cancer development and progression. Based on the generated K+ profile from different breast cancer cells, we aim for the specific manipulation of (sub)cellular K+ signals and concentrations within these cells and their organelles using “specific” K+ channel modulators. These imaging-based approaches will be complemented by the (correlative) assessment of
multiple cancer cell behavior parameters. Consequently, novel anti-cancer strategies and therapies based on the specific modulation of oncogenic K+ signals may evolve from our findings.
Schlüsselwörter:
GEPII
KCa3.1
Brustkrebs
breast cancer
BK
Beteiligte Mitarbeiter/innen
Leiter/innen
Mathematisch-Naturwissenschaftliche Fakultät
Universität Tübingen
Universität Tübingen
Pharmazeutisches Institut
Fachbereich Pharmazie und Biochemie, Mathematisch-Naturwissenschaftliche Fakultät
Fachbereich Pharmazie und Biochemie, Mathematisch-Naturwissenschaftliche Fakultät
Weitere Mitarbeiter/innen
Bischof, Helmut
Pharmazeutisches Institut
Fachbereich Pharmazie und Biochemie, Mathematisch-Naturwissenschaftliche Fakultät
Fachbereich Pharmazie und Biochemie, Mathematisch-Naturwissenschaftliche Fakultät
Lokale Einrichtungen
Fachbereich Pharmazie und Biochemie
Mathematisch-Naturwissenschaftliche Fakultät
Universität Tübingen
Universität Tübingen
Geldgeber
Bonn, Nordrhein-Westfalen, Deutschland