ProjectDFG SFB 1177 – Molecular and Functional Characterization of Selective Autophagy "Molecular function of WDR45/WIPI4…
Basic data
Acronym:
DFG SFB 1177
Title:
Molecular and Functional Characterization of Selective Autophagy "Molecular function of WDR45/WIPI4 in ferritinophagy and neurodegeneration"
Duration:
01/01/2020 to 31/12/2023
Abstract / short description:
De novo mutations in the WDR45/WIPI4 gene are causative for the human neurodegenerative disease BPAN (Beta-Propeller Associated Neurodegeneration), characterized by high iron accumulations in the brain. Normally, intracellular iron, stored as ferritin, is selectively degraded through ferritinophagy. In this project we will address the function of WDR45/WIPI4 in the process of ferritinophagy in both healthy and disease-associated (BPAN) conditions, using control- and patient-derived fibroblasts and thereupon derived iPS cells and in vitro differentiated neurons.
Involved staff
Managers
Faculty of Science
University of Tübingen
University of Tübingen
Research training group: MOMbrane: The multifaceted functions and dynamics of the mitochondrial outer membrane (MAM)
Research training groups
Research training groups
Research training group: Non-canonical G protein signaling pathways
Research training groups
Research training groups
Institute of Cell Biology (IZB)
Department of Biology, Faculty of Science
Department of Biology, Faculty of Science
Local organizational units
Interfaculty Institute for Cell Biology (IFIZ) †
Interfaculty Institutes
University of Tübingen
University of Tübingen
Funders
Bonn, Nordrhein-Westfalen, Germany