Advanced Model Systems Simulating Cell/Bacteria Interactions at the Interface between Implant and Soft Tissue

01/09/2019 to 31/08/2021

The main aim is to develop transgingival models that are able to simulate and predict soft tissue adhesion to implant surfaces under in vivo conditions, namely in presence of oral bacteria, i.e., the so-called “race for the surface”. Two main assays will be developed and evaluated: (i) Classic static co-cultivation of gingival fibroblasts and keratinocytes with bacteria on different titanium surfaces and (ii) dynamic online monitoring of adhesion and proliferation of both species using acoustic sensing in a flow system.