ProjektENTRUST-AF-PCI – Evaluation of the safety and efficacy of an edoxaban-basedcompared to a vitamin K…
Grunddaten
Akronym:
ENTRUST-AF-PCI
Titel:
Evaluation of the safety and efficacy of an edoxaban-basedcompared to a vitamin K antagonist-based antithrombotic regimenfollowing successful percutaneous coronary intervention (PCI)with stent placement. (EdoxabaN Treatment versus VKA inpatients with AF undergoing PCI)
Laufzeit:
25.09.2017 bis 31.12.2019
Abstract / Kurz- beschreibung:
The primary objective: is to compare a 12-month antithromboticregimen of edoxaban in combination with clopidogrel or another P2Y12 antagonist against a regimen of a vitamin K antagonist (VKA) in combination with clopidogrel or another P2Y12 antagonist and 1-12 months ASA in subjects with AF following successful PCI with stent placement in terms of the incidence of
major or clinically relevant non-major ISTH-defined bleeding (MCRB).
Secondary exploratory objectives of the study: are to compare the edoxaban-based antithrombotic regimen to the VKA-based antithrombotic regimen with regard to: Main efficacy endpoint (MEE), defined as the composite of cardiovascular (CV) death, stroke, systemic embolic events (SEE), spontaneous myocardial infarction (MI) and definite stent thrombosis; and more such as: bleeding, stroke, all-cause-death...
major or clinically relevant non-major ISTH-defined bleeding (MCRB).
Secondary exploratory objectives of the study: are to compare the edoxaban-based antithrombotic regimen to the VKA-based antithrombotic regimen with regard to: Main efficacy endpoint (MEE), defined as the composite of cardiovascular (CV) death, stroke, systemic embolic events (SEE), spontaneous myocardial infarction (MI) and definite stent thrombosis; and more such as: bleeding, stroke, all-cause-death...
Beteiligte Mitarbeiter/innen
Leiter/innen
Medizinische Universitätsklinik und Poliklinik (Department)
Kliniken und klinische Institute, Medizinische Fakultät
Kliniken und klinische Institute, Medizinische Fakultät
Medizinische Fakultät
Universität Tübingen
Universität Tübingen
Lokale Einrichtungen
Abteilung Innere Medizin III
Medizinische Universitätsklinik und Poliklinik (Department)
Kliniken und klinische Institute, Medizinische Fakultät
Kliniken und klinische Institute, Medizinische Fakultät
Geldgeber
Bad Homburg, Hessen, Deutschland