SFB TRR 156 C03

Impact of reactive oxygen species and NF-κB signaling during hapten-induced skin inflammation

01/07/2015 to 30/06/2019

The crosstalk of ROS and NF-κB signaling in inflammatory immune responses of the skin is still poorly understood. Thus, we aim to analyze how the temporal dynamics of ROS-induction translate into the activation of the canonical (p50) and non-canonical (p52) NF-κB signaling pathway. We will measure ROS generation and NF-κB activation non-invasively in vivo in mice with hapten-induced acute and chronic contact hypersensitivity reaction. Subsequently, we will focus on identifying the important ROS components, the cellular sources of ROS, differently regulated ROS target genes and will analyse the impact of ROS-induced NF-κB activation on leukocyte homing.