MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis

01/01/2017 to 31/12/2019

Mutations in genes encoding mitochondrial proteins underlie many human diseases with more
constantly being discovered. In addition gradual decline in mitochondrial function plays a role
in aging and complex disease phenotypes such as neurodegeneration and cancer. Our group
brings together scientist with complementary expertise that share a passion for understanding
the cross talk of mitochondria and the cellular environment. We propose to use this unifying
opportunity to shine a new light on an unexplored aspect of mitochondrial biology – how the
cross talk of mitochondria and the cell promotes homeostasis of the mitochondrial proteome
(proteostasis) in health and disease.