ProjectPARP inhibition in inherited retinal degeneration
Basic data
Title:
PARP inhibition in inherited retinal degeneration
Duration:
01/09/2015 to 30/09/2015
Abstract / short description:
Bridging funds for DFG proposal:PARP inhibition.
Poly-ADP-ribosylation (PARylation) is one of the most important post-translational modifications of histone proteins. As such it is involved in many cellular pathways including transcription, DNA repair, and cell death. Excessive PARP activity is also known to be involved in photoreceptor degeneration in various animal models for Retinitis Pigmentosa (Arango-Gonzalez 2014). Therefore, we will investigate the therapeutic potential of PARP inhibitors on inherited photoreceptor degeneration.
Poly-ADP-ribosylation (PARylation) is one of the most important post-translational modifications of histone proteins. As such it is involved in many cellular pathways including transcription, DNA repair, and cell death. Excessive PARP activity is also known to be involved in photoreceptor degeneration in various animal models for Retinitis Pigmentosa (Arango-Gonzalez 2014). Therefore, we will investigate the therapeutic potential of PARP inhibitors on inherited photoreceptor degeneration.
Involved staff
Managers
Sahaboglu Tekgöz, Ayse
Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine
Hospitals and clinical institutes, Faculty of Medicine
Local organizational units
Research Center for Ophthalmology
Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine
Hospitals and clinical institutes, Faculty of Medicine
Funders
Tübingen, Baden-Württemberg, Germany