ProjektPARP inhibition in inherited retinal degeneration
Grunddaten
Titel:
PARP inhibition in inherited retinal degeneration
Laufzeit:
01.09.2015 bis 30.09.2015
Abstract / Kurz- beschreibung:
Bridging funds for DFG proposal:PARP inhibition.
Poly-ADP-ribosylation (PARylation) is one of the most important post-translational modifications of histone proteins. As such it is involved in many cellular pathways including transcription, DNA repair, and cell death. Excessive PARP activity is also known to be involved in photoreceptor degeneration in various animal models for Retinitis Pigmentosa (Arango-Gonzalez 2014). Therefore, we will investigate the therapeutic potential of PARP inhibitors on inherited photoreceptor degeneration.
Poly-ADP-ribosylation (PARylation) is one of the most important post-translational modifications of histone proteins. As such it is involved in many cellular pathways including transcription, DNA repair, and cell death. Excessive PARP activity is also known to be involved in photoreceptor degeneration in various animal models for Retinitis Pigmentosa (Arango-Gonzalez 2014). Therefore, we will investigate the therapeutic potential of PARP inhibitors on inherited photoreceptor degeneration.
Beteiligte Mitarbeiter/innen
Leiter/innen
Sahaboglu Tekgöz, Ayse
Department für Augenheilkunde
Kliniken und klinische Institute, Medizinische Fakultät
Kliniken und klinische Institute, Medizinische Fakultät
Lokale Einrichtungen
Forschungsinstitut für Augenheilkunde
Department für Augenheilkunde
Kliniken und klinische Institute, Medizinische Fakultät
Kliniken und klinische Institute, Medizinische Fakultät
Geldgeber
Tübingen, Baden-Württemberg, Deutschland