ProjektiNKT – Tolerogenic Invariant Natural Killer T Cells for Protection from Lethal GVHD

Grunddaten

Akronym:
iNKT
Titel:
Tolerogenic Invariant Natural Killer T Cells for Protection from Lethal GVHD
Laufzeit:
01.07.2015 bis 30.06.2017
Abstract / Kurz- beschreibung:
Adoptively transferred iNKT cells protect from GVHD in murine models of allogeneic HCT through expansion and activation of donor Tregs but the humoral and cellular mechanisms underlying this phenomenon are poorly understood. We plan to elucidate the role of iNKT cells within the complex immunoregulatory network of Tregs, MDSCs and alloreactive T cells. We hypothesize that iNKT cells promote the expansion of donor Tregs through MDSCs in an IL-4/IL-13 dependent manner. Adoptively transferred iNKT cells secrete IL-4 and IL-13 which may both bind to the IL-4 receptor on MDSCs inducing cellular activation through STAT6 signaling. We plan to use different knock-in and knock-out mouse strains, monoclonal blocking antibodies, conventional flow cytometry, fluorescence-activated cell sorting, CyTOF and bioluminescence imaging together with our well-established murine models of allogeneic HCT. We hope that elucidating the precise mechanism of Treg expansion through iNKT cells might open new avenues to prevent GVHD which still causes significant morbidity and mortality after allogeneic HCT.
Schlüsselwörter:
Immunologie
immunology
Transplantation (transplantation)
Hämatopoetische Stammzellen (hematopoietic stem cells)
Regulatorische T-Zellen (regulatory T cells)
Immunologische Toleranz (immune tolerance)
Zelltherapie (cytotherapy)

Beteiligte Mitarbeiter/innen

Leiter/innen

Medizinische Fakultät
Universität Tübingen

Lokale Einrichtungen

Abteilung Innere Medizin II
Medizinische Universitätsklinik und Poliklinik (Department)
Kliniken und klinische Institute, Medizinische Fakultät

Geldgeber

Arlington Heights, Illinois, Vereinigte Staaten
Hilfe

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