Use of D-Cycloserine in Women with Bulimia Nervosa and OSFED

01/07/2015 to 30/05/2016

Mirror confrontation is an intervention that aims at a reduction of body-related fears and body dissatisfaction in eating disorders. Fear reduction in exposure-based therapy is similar to extinction learning and evidence suggests that extinction learning can be facilitated with D-cycloserine (DCS), a partial agonist at the glycine recognition site of the NMDA receptor in the amygdala. This project will therefore determine whether DCS improves extinction of body-related fears and body dissatisfaction in women with bulimia nervosa (BN) and subthreshold BN undergoing mirror exposure therapy.