MENDOS

Biomemetic Optical Sensors for Environmental Endocrine Disruptor Screening

01.01.2003 bis 31.12.2005

The main objective of this project is the development of novel artificial receptor based optical sensor systems and their application for assessing and screening endocrine disrupting compounds (EDCs). Biomimetic interfaces based on molecularly imprinted polymers (MIPs) will be developed. Characterization and optimization of the biomimetic layer will be achieved by using advanced analytical techniques. Optical transducers will be developed for the biomimetic sensors. The results of systems using Biosensors for EDCs, which will be based on whole cell systems and DNA chips, will be related to the MIPs results. This should allow to evaluate the (eco)toxicological significance of the MIPs output. A biomimetic sensing system prototype(s) will be assembled and will be tested under real word conditions.