ProjektDANIO-ReCODE – DANIO-CODE - the next frontier: Decoding transcription regulation in regeneration by advanced…
Grunddaten
Akronym:
DANIO-ReCODE
Titel:
DANIO-CODE - the next frontier: Decoding transcription regulation in regeneration by advanced genomics and computational tools
Laufzeit:
01.11.2024 bis 31.10.2028
Abstract / Kurz- beschreibung:
The principal objective of DANIO-ReCODE is to provide world-class doctoral training to a new generation of early-career researchers
interested in understanding the complex and multilayered process of tissue regeneration. DANIO-ReCODE will combine the
multidisciplinary expertise of 15 research laboratories at renowned EU and UK scientific institutions to unravel the regulatory
mechanisms of heart, brain, and eye regeneration by employing the unique and highly tractable zebrafish model system. Unlike humans,
teleosts can repair damaged tissues or even regrow entire appendages. In mammals, regeneration is rare, limited to skin, liver, and toes.
Regenerative medicine, however, promises to restore tissue function via the use of stem cells, tissue engineering, and the production
of artificial organs, with its importance being recognised as one of the EU strategic missions. A fundamental gap of knowledge is the
understanding of the shared and distinct regulatory mechanisms defining regeneration in highly regenerative species and those with
lower regeneration potential such as mammals. Since the vertebrate gene complement is highly conserved, applying the knowledge of
regeneration mechanisms from non-mammalian models such as zebrafish could identify genetic underpinnings, which when manipulated
in mammals, could strongly boost the mammalian regenerative potential. DANIO-ReCODE will thus nurture a cohort of exceptional
doctoral candidates and turn them into interdisciplinary experts in computational and developmental biology, providing comprehensive
training that spans experimental work, bioinformatics, visualisation, and industry applications. Through the integration of state-of-theart
genomics, computational, and data visualisation techniques, DANIO-ReCODE will result in an enhanced understanding of molecular
determinants implicated in vertebrate regenerative processes while providing new avenues for the repair or replacement of damaged or
diseased tissues and organs.
interested in understanding the complex and multilayered process of tissue regeneration. DANIO-ReCODE will combine the
multidisciplinary expertise of 15 research laboratories at renowned EU and UK scientific institutions to unravel the regulatory
mechanisms of heart, brain, and eye regeneration by employing the unique and highly tractable zebrafish model system. Unlike humans,
teleosts can repair damaged tissues or even regrow entire appendages. In mammals, regeneration is rare, limited to skin, liver, and toes.
Regenerative medicine, however, promises to restore tissue function via the use of stem cells, tissue engineering, and the production
of artificial organs, with its importance being recognised as one of the EU strategic missions. A fundamental gap of knowledge is the
understanding of the shared and distinct regulatory mechanisms defining regeneration in highly regenerative species and those with
lower regeneration potential such as mammals. Since the vertebrate gene complement is highly conserved, applying the knowledge of
regeneration mechanisms from non-mammalian models such as zebrafish could identify genetic underpinnings, which when manipulated
in mammals, could strongly boost the mammalian regenerative potential. DANIO-ReCODE will thus nurture a cohort of exceptional
doctoral candidates and turn them into interdisciplinary experts in computational and developmental biology, providing comprehensive
training that spans experimental work, bioinformatics, visualisation, and industry applications. Through the integration of state-of-theart
genomics, computational, and data visualisation techniques, DANIO-ReCODE will result in an enhanced understanding of molecular
determinants implicated in vertebrate regenerative processes while providing new avenues for the repair or replacement of damaged or
diseased tissues and organs.
Beteiligte Mitarbeiter/innen
Leiter/innen
Wilhelm-Schickard-Institut für Informatik (WSI)
Fachbereich Informatik, Mathematisch-Naturwissenschaftliche Fakultät
Fachbereich Informatik, Mathematisch-Naturwissenschaftliche Fakultät
Interfakultäres Institut für Biomedizinische Informatik (IBMI)
Interfakultäre Institute
Interfakultäre Institute
Lokale Einrichtungen
Interfakultäres Institut für Biomedizinische Informatik (IBMI)
Interfakultäre Institute
Universität Tübingen
Universität Tübingen
Geldgeber
Brüssel, Belgien
Kooperationen
Madrid, Spanien