GoE

Genome of Europe

01.10.2024 bis 31.03.2028

The Genome of Europe (GoE) project encompasses 48 partners across 27 European countries (26 EU+1 non-EU) to establish a unique
pan-European reference database comprising a minimum of 100,000 genomes representative of European citizens in alignment with
the 1+ Million Genomes initiative. Key objectives include implementing a pan-European community of practice that will generate
the reference genome through integration of existing genome datasets and de novo sequencing from diverse national populations,
defining the ethical, legal and societal conditions for generating the reference genome, ensuring data security, and embedding
GoE data within the Digital Europe Programme-funded Genomic Data Infrastructure. The value and usability of the GoE will be
assessed through use cases focusing on genetic diversity, establishing multi-ancestry imputation services, and recalibrating genetic risk
profiles. Beyond the project, GoE will be highly relevant for genetic-phenotypic discoveries, helping national genome programs, and
integration of genomics into the European Health Data Space (EHDS). The GoE project prioritizes public engagement, transparency,
and adaptability for future extensions, ensuring responsible and sustainable genomic advancements. Integration with other European
initiatives enhances its potential impact for personalized medicine, and aligns with broader scientific and healthcare goals including the
European competitiveness in genomic research and innovation.