ProjectAufklärung der Auswirkungen von C3b-Abbauprodukten auf die mikrogliale Aktivierung und Neurodegeneration in der…
Basic data
Title:
Aufklärung der Auswirkungen von C3b-Abbauprodukten auf die mikrogliale Aktivierung und Neurodegeneration in der Pathogenese der altersbedingten Makuladegeneration (AMD)
Duration:
01/08/2024 to 30/07/2027
Abstract / short description:
Age-related macular degeneration (AMD) is a degenerative eye disease causing blindness in the elderly population. The role of complement over-activation in AMD has given rise to many complement targeting therapeutics being developed. However, existing therapeutics have limited efficacy, probably because they have been solely focused on switching off complement turnover rather than also addressing the downstream opsonisation effect of C3b breakdown products on retinal tissue remodelling through microglia/RPE mediated phagocytosis. Remarkably, we still do not fully understand the effect of each opsonin on microglia or RPE cell molecular pathways, and therefore how best to ‘switch-off’ the subsequent excessive tissue remodelling observed in AMD. Prof. Simon Clark aims to investigate the intricate molecular consequences on microglia/RPE after engagement with each C3b breakdown opsonin (i.e. C3b>iC3b>C3dg>C3d each showing decreasing opsonisation potency).
Keywords:
microglia
age-related macular degeneration
complement
opsonisation
Involved staff
Managers
Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine
Hospitals and clinical institutes, Faculty of Medicine
Other staff
Universität Tübingen
Local organizational units
University Eye Hospital
Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine
Hospitals and clinical institutes, Faculty of Medicine
Funders
Bonn, Nordrhein-Westfalen, Germany