Comparative analysis of retinal ON and OFF pathways in emmetropic and myopic eyes

01/12/2023 to 30/11/2024

The prevalence of myopia is increasing rapidly around the world. With the multiplied risk of severe eye diseases being related to this refractive error, a better understanding of its development and improved and novel treatment strategies for reducing its progression are urgently needed. Based on different animal models, myopia was found to be related to defects in the visual ON pathway. Further research in humans suggested more potent OFF pathway-mediated signals in myopic eyes. In this project, we aim to assess the retinal ON and OFF pathways comparatively in eyes with emmetropia and myopia using visual electrophysiology. The results might contribute to increasing current knowledge on myopia onset and its risk factors, and initiate novel therapeutic approaches.