ProjektGET-IN – The GEne Therapy INnovation Training Network

Grunddaten

Akronym:
GET-IN
Titel:
The GEne Therapy INnovation Training Network
Laufzeit:
01.09.2023 bis 31.08.2027
Abstract / Kurz- beschreibung:
Gene therapy has transitioned from a distant hope to reality. To date 3 rAAV gene therapies are approved in the EU, >30 phase III clinical trials ongoing, and exciting developments in therapeutic gene editing in the pipeline. However, fundamental limitations in the bioprocessing of gene therapy vectors limit broader application. Manufacturing is not automated, with an open process environment, limited scalability and robustness, and inefficient downstream processing, resulting in huge footprint and exceedingly high cost of goods. The field requires scalable manufacturing technology with modular design to produce high doses for large patient groups at a fraction of cost. Improved delivery approaches with increased specificity and efficacy at lower doses are needed to overcome emerging safety concerns observed in clinical trials. Prediction of therapeutic efficacy in man is challenging due to a species barrier, underlining the need for humanized models to reduce attrition rates in the development pipeline.
To overcome these challenges, innovation driven by multidisciplinary approaches is direly needed. GET-IN is a doctoral network of 7 academic and 8 non-academic partners, with expertise in vectorology, genome editing, process engineering, biomanufacturing and innovative humanized models. Together, they provide an excellent training framework for 10 Doctoral Candidates (DCs) who will be the future innovators in the gene therapy field. Research in GET-IN will investigate disruptive innovations including optimised bioprocessing, digital simulation, novel and improved vectors and genome editors, targeted delivery systems, and human organ-on-chip models for more relevant safety and efficacy evaluation. The joint training programme will emphasise responsible, cooperative research and innovation, creativity, and entrepreneurship to maximize the career potential of the DCs.

Beteiligte Mitarbeiter/innen

Leiter/innen

Abteilung Mikrophysiologische Systeme
Institut für Biomedical Engineering (IBE), Nichtklinische Institute, Medizinische Fakultät

Weitere Mitarbeiter/innen

Medizinische Fakultät
Universität Tübingen

Lokale Einrichtungen

Medizinische Fakultät
Universität Tübingen

Geldgeber

Brüssel, Belgien
Hilfe

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