ProjectNFDI4Immuno – National Research Data Infrastructure for Immunology (NFDI4Immuno)

Basic data

National Research Data Infrastructure for Immunology (NFDI4Immuno)
01/03/2023 to 29/02/2028
Abstract / short description:
The immune system plays a fundamental role in health and disease and efficiently protects vertebrate hosts from infections and cancer. However, failures in its regulation can cause autoimmunity, allergy, immunodeficiencies and malignancies. To perform the critical task of self/non-self recognition, the innate immune system employs genomically fixed pattern recognition receptors. The adaptive immune system, however, utilizes billions of randomly generated immunoglobulins/antibodies and T cell receptors (hereafter: adaptive immune receptors), which are expressed by cells of the B cell and T cell lineage, respectively. The phenotype, functionality, activation state and anatomic location of these cells, as well as the adaptive immune receptor repertoire (AIRR) of an individual host, are reflective of the key processes within the immune system: diversification, selection, antigen recognition and clonal expansion. A comprehensive insight into these processes will facilitate a mechanistic understanding and advance the development of diagnostic markers and novel therapeutic strategies.
The main objective of NFDI4Immuno is therefore to provide the capability to combine data and metadata from diverse experimental technologies, such as cytometry, sequencing, immunoassay and imaging, which provide complementary observations of these processes. To this end, the consortium will 1) harmonize data representations, metadata standards, ontologies and programmatic interfaces with other NFDI consortia to facilitate queries and cross-references across consortia, 2) provide consistent metadata annotation to existing and new data sets and make them available through its repositories, 3) enable and support users to utilize the resources provided by the consortium and promote the adoption of FAIR practices by the immunological
community, in support of the cultural change towards Open Science, 4) build and operate a network of federated repositories for immunological data and 5) develop tools and services that will facilitate standardized and reproducible data analyses. On the national level, the consortium will closely collaborate with the German Society for Immunology (DGfI) and the German Society for Cytometry (DGfZ) as well as the NFDI consortia NFDI4Microbiota, InnoMatSafety, NFDI4BIOIMAGE, GHGA and NFDI4Health. Beyond the national scope, NFDI4Immuno will connect with various international activities, e.g., IUIS, ISAC,
EBCnet, IEDB, EuroClonality, iReceptor Plus and the AIRR Community.

Involved staff


Wilhelm Schickard Institute of Computer Science (WSI)
Department of Informatics, Faculty of Science
Quantitative Biology Center (QBIC)
Central cross-faculty facilities
Institute for Bioinformatics and Medical Informatics (IBMI)
Interfaculty Institutes

Other staff

Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes
Department of Systems Neuroscience
Hertie Institute for Clinical Brain Research (HIH), Non-clinical institutes, Faculty of Medicine
Quantitative Biology Center (QBIC)
Central cross-faculty facilities

Local organizational units

Quantitative Biology Center (QBIC)
Central cross-faculty facilities
University of Tübingen


Bonn, Nordrhein-Westfalen, Germany

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