ProjectTranscranial brain stimulation to study memory processing and synaptic plasticity during sleep

Basic data

Title:
Transcranial brain stimulation to study memory processing and synaptic plasticity during sleep
Duration:
01/02/2023 to 31/01/2027
Abstract / short description:
This project investigates the oscillatory mechanisms mediating information abstraction and underlying synaptic rescaling during sleep using real-time EEG-triggered transcranial magnetic stimulation (TMS) of the primary motor cortex and transcranial ultrasonic stimulation (TUS) of the thalamus in humans (i) to characterize the excitation-inhibition-balance during sleep spindles and slow oscillations, (ii) to establish spindles/slow oscillations as windows of plasticity that enable synaptic rescaling during sleep, and (iii) to demonstrate that spindles are causally relevant for information abstraction during systems consolidation.
Keywords:
sleep
Schlaf
memory
Gedächtnis
Synaptische Plastizität
Transkranielle Hirnstimulation
Transkranielle Magnetstimulation
Transkranielle Ultraschallstimulation

Involved staff

Managers

University Department of Neurology
Hospitals and clinical institutes, Faculty of Medicine

Contact persons

University Department of Neurology
Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

Department of Neurology with Focus on Neurovascular Diseases
University Department of Neurology
Hospitals and clinical institutes, Faculty of Medicine

Funders

Bonn, Nordrhein-Westfalen, Germany
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