3D skin models

01/07/2023 to 30/06/2027

Three dimensional (3D) organotypic cultures have emerged as valuable tools in skin research, replacing animal experiments in many cases and precluding the need for repeated patient biopsies. Based on our long-standing expertise in human 3D skin models we advanced our existing models to model inflammatory skin diseases including fibrosis, atopic dermatitis and psoriasis and were successful in the integration of immune cells into 3D human skin models. Using these advanced 3D skin models, we were able to simulate several human inflammatory skin diseases in a physiological environment. Based on the needs of the principal investigators we will use these models for preclinical therapy approaches, basic immunological research questions or to study the influence of skin inflammation on skin infection.