ProjektDAPT Substudie – National Biomarker / Platelet Function sub-study of DAPT-SHOCK Trial
Grunddaten
Akronym:
DAPT Substudie
Titel:
National Biomarker / Platelet Function sub-study of DAPT-SHOCK Trial
Laufzeit:
23.12.2021 bis 31.12.2023
Abstract / Kurz- beschreibung:
To evaluate the effect of cangrelor + ticagrelor versus placebo + ticagrelor on biomarker expression and platelet function in cardiogenic shock patients undergoing PCI:
Inhibition of platelet function at the end of PCI as measured by agonist induced platelet aggregation at the end of PCI.
Course of platelet function, platelet reactivity as measured by various platelet activation markers and monocyte activation measured by flow cytometry over time.
Biomarker analysis of soluble platelet dependent and systemic inflammatory markers (e.g. Interleukin 1/6, CD40L, TNF alpha, VEGF, HMGB1)
1:1 Comparison between patients randomized to cangrelor versus placebo
Inhibition of platelet function at the end of PCI as measured by agonist induced platelet aggregation at the end of PCI.
Course of platelet function, platelet reactivity as measured by various platelet activation markers and monocyte activation measured by flow cytometry over time.
Biomarker analysis of soluble platelet dependent and systemic inflammatory markers (e.g. Interleukin 1/6, CD40L, TNF alpha, VEGF, HMGB1)
1:1 Comparison between patients randomized to cangrelor versus placebo
Beteiligte Mitarbeiter/innen
Leiter/innen
Medizinische Universitätsklinik und Poliklinik (Department)
Kliniken und klinische Institute, Medizinische Fakultät
Kliniken und klinische Institute, Medizinische Fakultät
Ansprechpartner/innen
Medizinische Fakultät
Universität Tübingen
Universität Tübingen
Weitere Mitarbeiter/innen
Medizinische Fakultät
Universität Tübingen
Universität Tübingen
Lokale Einrichtungen
Abteilung Innere Medizin III
Medizinische Universitätsklinik und Poliklinik (Department)
Kliniken und klinische Institute, Medizinische Fakultät
Kliniken und klinische Institute, Medizinische Fakultät
Geldgeber
Herzogenrath, Nordrhein-Westfalen, Deutschland