CSF neuroinflammatory signature in Alzheimer's disease and related proteopathies

01/11/2022 to 31/10/2024

The reaction of glial cells plays a central role in the pathogenesis of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. However, measurable parameters to monitor this process in patients are still largely lacking. With the funding from the Cure Alzheimer's Fund, we now plan to identify a set of CSF markers that reflect neuroinflammatory stages in the brain. We then aim to develop a multipley assay that could be used to assess glial activation in liquid biopsies.