Portfolio Prof. Dr. Alfred Nordheim

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Academic title:
Prof. Dr.
Name:
Alfred Nordheim
Organizational units:
Faculty of Science
University of Tübingen
Interfaculty Institute for Cell Biology (IFIZ)
Interfaculty Institutes

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Curriculum vitae

Research focus

Our main research interest is directed toward understanding molecular mechanisms by which intracellular signalling elicits differential genomic responses at the level of transcription. Primarily, we are interested in gene expression under the control of the transcription factor SRF (Serum Response Factor). This transcription factor controls target gene expression by recruiting to its DNA binding sites (CArG boxes) different SRF co-factors which by themselves are subject to regulation by intracellular signalling cascades.The most important families of SRF co-factors are the TCFs (ternary complex factors) and the Myocardin/MRTF proteins. Whereas the former are under control of mitogenic MAPK signalling, the latter respond to dynamical changes in the actin cytoskeleton.

Patents

10/06/2005
02/11/2005 (PCT Registration)
Alfred Nordheim, Tassula Proikas-Cezanne
17/10/2005
17/10/2006 (PCT Registration)
Bernd Knöll, Alfred Nordheim

Projects

2019 - 2025
Lars Zender, Bernd Pichler, Hans-Georg Rammensee
Deutsche Forschungsgemeinschaft e.V. (DFG)
2017 - 2021
Alfred Nordheim
Deutsche Forschungsgemeinschaft e.V. (DFG)

Publications

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