Project Dissecting cell type-specific effects of maternal immune activation on the human fetal neocortical development

Basic data

Title:
Dissecting cell type-specific effects of maternal immune activation on the human fetal neocortical development
Duration:
01/04/2021 to 31/03/2022
Abstract / short description:
It is commonly accepted that maternal inflammation is correlated with adverse
neurodevelopmental outcomes in offspring. Given that 64% of pregnant women experience
infectious diseases, revealing mechanisms that translate maternal inflammation to changes
in fetal neurodevelopment has a major clinical importance. In my doctoral project, I plan to
gain a systematic understanding of the cell type-specific effects of maternal immune
activation during different stages of human fetal neocortical development. For that purpose, I
will use brain organoids as a model system and will employ high-end techniques such as
single-cell RNA-Sequencing. Additionally, I will characterize molecular pathways on the
protein level. The results of my project can be potentially used in clinics for timely treatment
of the fetus and prevention of downstream consequences of maternal inflammation.

Involved staff

Managers

University Department of Neurology
Hospitals and clinical institutes, Faculty of Medicine
University Department of Neurology
Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

University Department of Neurology
Hospitals and clinical institutes
Faculty of Medicine
Help

will be deleted permanently. This cannot be undone.