Project DFG SFB 1177 – Molecular and Functional Characterization of Selective Autophagy "Molecular function of WDR45/WIPI4…

Basic data

Acronym:
DFG SFB 1177
Title:
Molecular and Functional Characterization of Selective Autophagy "Molecular function of WDR45/WIPI4 in ferritinophagy and neurodegeneration"
Duration:
01/01/2020 to 31/12/2023
Abstract / short description:
De novo mutations in the WDR45/WIPI4 gene are causative for the human neurodegenerative disease BPAN (Beta-Propeller Associated Neurodegeneration), characterized by high iron accumulations in the brain. Normally, intracellular iron, stored as ferritin, is selectively degraded through ferritinophagy. In this project we will address the function of WDR45/WIPI4 in the process of ferritinophagy in both healthy and disease-associated (BPAN) conditions, using control- and patient-derived fibroblasts and thereupon derived iPS cells and in vitro differentiated neurons.

Involved staff

Managers

Faculty of Science
University of Tübingen
Interfaculty Institute for Cell Biology (IFIZ)
Interfaculty Institutes

Local organizational units

Interfaculty Institute for Cell Biology (IFIZ)
Interfaculty Institutes
University of Tübingen

Funders

Bonn, Nordrhein-Westfalen, Germany
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