Project MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis

Basic data

Title:
MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis
Duration:
01/01/2020 to 31/12/2021
Abstract / short description:
Mutations in mitochondrial genes underlie many human diseases with more constantly being discovered. In addition gradual decline in mitochondrial function plays a role in complex disease phenotypes such as neurodegeneration, aging and cancer. Our group brings together experts from different fields that share a passion for understanding the cross talk of mitochondria and the cellular environment. We propose to use this unifying opportunity to shine a new light on a little-explored aspect of mitochondrial biology – how the cross talk of mitochondria and the cell promotes homeostasis of the mitochondrial proteome (proteostasis) in health and disease.

Involved staff

Managers

Faculty of Science
University of Tübingen
Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes

Local organizational units

Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes
University of Tübingen

Funders

Bonn, Nordrhein-Westfalen, Germany
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