Project 3000035226:

Basic data

01/01/2020 to 31/12/2021
Abstract / short description:
Environmental enteric dysfunction (EED) is a poorly understood inflammatory syndrome characterized by reduced absorptive capacity and barrier function in the small intestine. It is widespread among children in low-income countries and impairs child growth and develpment (stunting). Although various infectious agents have been suggested to cause EED, recent evidence supports the idea that a "decompartmentalization" of intrinsic throat microbes towards the small intestine cobined with a depletion of beneficial butyrate-producing microbes sustains inflammatory conditions. The overarching goal of this study is to identify lead compounds, drugs or drug/food combinations that modulate the gastrointestinal microbiome in stunted children towards a healthy microbial community.

Involved staff


Faculty of Medicine
University of Tübingen

Local organizational units

Institute of Medical Microbiology and Hygiene
Department of Diagnostic Laboratory Medicine
Hospitals and clinical institutes, Faculty of Medicine

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