Project Bedeutung von Thrompozytären Entzündungsmediatorenin der degenerativen Aortenklappenerkrankung und in der…

Basic data

Title:
Bedeutung von Thrompozytären Entzündungsmediatorenin der degenerativen Aortenklappenerkrankung und in der subklinischen Endokarditis
Duration:
01/07/2018 to 30/06/2022
Abstract / short description:
Degenerative aortic valve disease is the second most common heart disease in adults and predisposes
for life-threatening endocarditis. Inflammation is a prominent feature of disease progression. Platelets
drive the thrombo-inflammatory response. At the site of valve injury, platelets release inflammatory and
antimicrobial chemokines that influence the inflammatory and immune defense system of affected
valves. We will elaborate the role of platelet-derived chemokines in the pathophysiology of inflammatory
aortic valve disease using a variety of genetic mouse strains, infection models, and - for the first
time – in human material to identify novel diagnostic and therapeutic strategies.

Involved staff

Managers

Faculty of Medicine
University of Tübingen

Contact persons

Faculty of Medicine
University of Tübingen

Local organizational units

Internal Medicine Department II
Department of Internal Medicine
Hospitals and clinical institutes, Faculty of Medicine

Funders

Bonn, Nordrhein-Westfalen, Germany
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