Project Mechano-cGMP – A new role of cGMP in platelet mechanotransduction

Basic data

Acronym:
Mechano-cGMP
Title:
A new role of cGMP in platelet mechanotransduction
Duration:
01/07/2018 to 30/06/2022
Abstract / short description:
Using technology to “watch” cGMP signals in real time in living platelets, we discovered that NO-induced cGMP signals in platelets strongly depend on flow/shear stress. In this project, we will study the molecular mechanism and in vivo relevance of mechanosensitive cGMP signalling in platelets. We hypothesise that it acts as an auto-regulatory break to limit thrombosis under high shear. Unlike existing anti-thrombotic therapies, drugs that activate the shear-dependent cGMP brake should not increase the risk of bleeding.
Keywords:
cGMP
cyclic guanosine monophosphate, Cyclisches Guanosinmonophosphat
FRET
Förster resonance energy transfer, Förster-Resonanzenergietransfer
signal transduction
Signaltransduktion
platelets
mechanobiology
transgenic mice

Involved staff

Managers

Faculty of Science
University of Tübingen
Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes
Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes

Local organizational units

Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes
University of Tübingen

Funders

Bonn, Nordrhein-Westfalen, Germany
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