Project Optimisation of the lysolipins, potent broad spectrum antibiotics from the actinomycete Streptomyces

Basic data

Title:
Optimisation of the lysolipins, potent broad spectrum antibiotics from the actinomycete Streptomyces
Duration:
15/02/2018 to 14/02/2019
Abstract / short description:
Lysolipin I is an extraordinarily potent antibacterial natural product, with an MIC in the low nanomolar range against Gram-positive organisms and a higher, but still nanomolar MIC against Gram-negative microorganisms. Its mechanism of action is not yet fully understood. However, its usability as antibacterial agent is limited due to the fact that is also shows cytotoxicity. First experiments have shown that structural modifications of the lysolipin core structure can differentially influence antibacterial activity and cytotoxicity.
The aim of the proposed project is to develop a lysolipin derivative as ADMET profiled clinical development candidate by structure optimisation via both chemical and molecular biology strategies in early 2018. This goal will be achieved by a combination of state-of-the-art fermentation technology, natural product analysis and molecular biology with the aim of optimizing the activity as well as the toxicity profile of lysolipin I.

Staff

Managers

Faculty of Science
University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine (IMIT)
Interfaculty Institutes
Interfaculty Institute of Microbiology and Infection Medicine (IMIT)
Interfaculty Institutes

Local organizational units

Interfaculty Institute of Microbiology and Infection Medicine (IMIT)
Interfaculty Institutes
University of Tübingen

Funders

Braunschweig, Niedersachsen, Germany
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