Project SICOPID – Activation and regulation of plasma membrane receptor signaling complexes controlling plant development…

Basic data

Acronym:
SICOPID
Title:
Activation and regulation of plasma membrane receptor signaling complexes controlling plant development and immunity, and their connection to downstream signaling cascades
Duration:
01/05/2018 to 30/04/2021
Abstract / short description:
Plants are nature’s other successful experiment with multicellular life. To coordinate growth and
development of their cells, tissues and organs plants have evolved unique plasma membrane receptor
kinases (RKs). Several members of this protein family function as pattern recognition receptors, and as
hormone receptors shaping the architecture of the plant. There is mounting evidence that different plant
RKs are organized in membrane signaling complexes. RKs have a common structural architecture and
share downstream signaling components. As such, it is presently unclear how the recognition of specific
endogenous or foreign signals at the cell surface is translated into the activation of specific
developmental programs or immune responses in the cytosol. We propose to combine physiology,
genetics and cell biology with phosphoproteomics, quantitative biochemistry and structural biology to
identify the shared and specific mechanisms by which plant developmental and immune receptor
complexes are activated. We will dissect, in molecular detail, how activated receptor complexes
generate specific signaling output in the cytosol and how the activity of plant RKs are regulated by
inhibitor proteins. We envision that our work will provide a molecular framework for understanding
how specificity is encoded at the molecular level in RK signaling, setting the stage for engineering
these pathways in crops in the future.
Keywords:
Arabidopsis thaliana
thale cress, Acker-Schmalwand
plant immunity
receptor kinase
phosphoproteomics

Involved staff

Managers

Faculty of Science
University of Tübingen
Center for Plant Molecular Biology (ZMBP)
Department of Biology, Faculty of Science

Local organizational units

Plant Biochemistry Research Group at ZMBP
Department of Pharmacy and Biochemistry
Faculty of Science

Funders

Bonn, Nordrhein-Westfalen, Germany
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