Project Cellular responses to canonical and non-canonical mistranslations

Basic data

Title:
Cellular responses to canonical and non-canonical mistranslations
Duration:
01/01/2018 to 31/12/2019
Abstract / short description:
The aim of this project is to address the mechanism of mistranslation-induced toxicity in Escherichia coli and the cellular responses aimed to undo the damaging effects of mistranslation using biochemical approaches in combination with quantitative proteomics. In particular, we are interested in comparison of canonical and non-canonical mistranslation on all points to tackle the constraints that likely draw selection of the canonical amino acid protein alphabet.
Keywords:
Mistranslation
tRNA Synthatase
Proteomics

Staff

Managers

Faculty of Science
University of Tübingen
Department of Biology
Faculty of Science

Local organizational units

Interfaculty Institute for Cell Biology (IFIZ)
Interfaculty Institutes
University of Tübingen

Funders

Bonn, Nordrhein-Westfalen, Germany
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