Project NIGRASTEER – Lateral steering of nigral stimulation for freezing of gait in Parkinson's disease

Basic data

Acronym:
NIGRASTEER
Title:
Lateral steering of nigral stimulation for freezing of gait in Parkinson's disease
Duration:
01/02/2018 to 31/01/2021
Abstract / short description:
Substantial efforts are ongoing in order to establish nigral stimulation for freezing of gait in Parkinson’s disease resistant to standard therapy. Currently, freezing of gait represents a largely unmet therapeutic need in intermediate and advanced disease stages and severely deteriorates quality of life. A multicentre trial is ongoing to this end (NCT02588144; Investigator-initiated trial, coordinated by the Tübingen Centre). Nevertheless, the technological advancement from directional steering enables now to explore functional subterritories in the substantia nigra in order to improve i) efficacy, ii) safety, and to facilitate iii) future neurosurgical targeting approaches when referring to nigral subterritories in addition to standard STN stimulation. Moreover, intraoperative electrophysiological surrogates obtained from the directional lead (local field potentials, evoked potentials), as well as its connectivity to the cortical surface (EEG), are expected to inform neurosurgeons and neurologists on optimal lead placement and postoperative programming, given that electrophysiological signatures like oscillatory activity or neuronal synchronization present with substantial abnormality in freezing of gait. With this proposal, we expect to facilitate the concept of nigral stimulation for freezing of gait by taking advantage from cutting-edge steering technology and multiple independent current sources.

Involved staff

Managers

Department of Neurosurgery
Hospitals and clinical institutes, Faculty of Medicine
Faculty of Medicine
University of Tübingen

Local organizational units

Department of Neurosurgery
Hospitals and clinical institutes
Faculty of Medicine
Department of Neurology with Focus on Neurodegenerative Disorders
University Department of Neurology
Hospitals and clinical institutes, Faculty of Medicine

Funders

Ratingen, Nordrhein-Westfalen, Germany
Help

will be deleted permanently. This cannot be undone.