Project SFB TRR 156 C03 – Impact of reactive oxygen species and NF-κB signaling during hapten-induced skin inflammation

Basic data

Acronym:
SFB TRR 156 C03
Title:
Impact of reactive oxygen species and NF-κB signaling during hapten-induced skin inflammation
Duration:
01/07/2015 to 30/06/2019
Abstract / short description:
The crosstalk of ROS and NF-κB signaling in inflammatory immune responses of the skin is still poorly understood. Thus, we aim to analyze how the temporal dynamics of ROS-induction translate into the activation of the canonical (p50) and non-canonical (p52) NF-κB signaling pathway. We will measure ROS generation and NF-κB activation non-invasively in vivo in mice with hapten-induced acute and chronic contact hypersensitivity reaction. Subsequently, we will focus on identifying the important ROS components, the cellular sources of ROS, differently regulated ROS target genes and will analyse the impact of ROS-induced NF-κB activation on leukocyte homing.

Staff

Managers

Faculty of Medicine
University of Tübingen

Local organizational units

Department of Preclinical Imaging and Radiopharmacy
Department of Radiology
Hospitals and clinical institutes, Faculty of Medicine

Funders

Bonn, Nordrhein-Westfalen, Germany
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