Project Early Brain Plasticity - Network Reorganization in the "Healthy" Hemisphere?

Basic data

Title:
Early Brain Plasticity - Network Reorganization in the "Healthy" Hemisphere?
Duration:
01/11/2017 to 31/10/2019
Abstract / short description:
The theoretical framework of early plasticity research is shifting from a modular towards a systemic view. Focal unilateral brain lesions acquired pre-/perinatally or during childhood provide an optimal model for investigating the developing brain’s potential to compensate tissue loss by functional reorganization. In the last decades, data and models on structural and functional reorganization of somatosensory functions and on functional reorganization of language have been provided. In consequence, a prominent research question concerns the effects of a lesion on the formation of contralesional structural and functional networks. The main goals of the proposed study are to investigate
1. how an early unilateral lesion affects loss and gain in volume (non-specific hemispherical vs. specific fibre tracts) in the contralesional hemisphere,
2. how performance is related to the integrity of reorganized contralesional networks, and
3. if there is a modulating effect of age at lesion and presence/absence of epileptic activity on the formation of contralesional networks
Keywords:
network
Netzwerk
Neuroplastizität (neuroplasticity)
frühkindliche Hirnschädigung (early brain lesion)

Involved staff

Managers

Faculty of Medicine
University of Tübingen
Faculty of Medicine
University of Tübingen

Contact persons

Faculty of Medicine
University of Tübingen
Faculty of Medicine
University of Tübingen

Local organizational units

Paediatrics Department III and Polyclinic
University Children’s Hospital - Department of Paediatrics
Hospitals and clinical institutes, Faculty of Medicine

Funders

Bonn, Nordrhein-Westfalen, Germany
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